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 Objectives
Research support platform whose main objective is to promote the development of any DNA / RNA study on a massive scale, either in humans or in other organisms. The activity of the platform is aimed at advising scientists and researchers on the possibilities and benefits obtained from the application of computational biology techniques in their research. In addition, researchers will be supported in the analysis and interpretation of data obtained using high-throughput experimental techniques.
Composition
Coordinator
Alejandro Pascual Iglesias
Phone: +34 91 207 15 12
Documentation
Operation
The procedure to follow is as follows:
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Fill in the "Job Application" form and send it to carolina.rubio.martin@idipaz.es. Fill in what you want to do by means of a short memory in which the primary objective of the study and the secondary objectives, if any, are clearly specified.
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Meeting with the Bioinformatics Platform to share questions such as the sample size with which it is going to work, the statistical power to be obtained and the variables to be analysed.
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Preparation and delivery of the data to be analysed in the format previously agreed between both parties.
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Carrying out the analysis.
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Delivery of results in the pertinent formats.
Portfolio of Services/Prices
1. Experimental design. Advice to decide the sample size, the design of the study and the planning of the methodology.
2. Data analysis. The bioinformatics processing of the data obtained is carried out in various high-performance technological platforms used in the field of genomics. These analyses include normalization, statistical analysis, and representation of the results. The most common analyses are:
Differential expression of genes, miRNAs or lncRNAs. The technology of origin of the experiments can be microarrays (Affymetrix, Agilent) or RNA-seq (Illumina, Ion Torrent):
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Protein-DNA interactions from immunuprecipitation and microarray (ChIP-chip) or sequencing (ChIP-seq) experiments.
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Helps to interpret results. Once the genes of interest have been selected, biological-functional assignment studies are carried out, such as the study of functional enrichment of gene / protein lists.
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Design, implementation and administration of databases (eg of patients, samples, etc.).
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Individualized training activities: Training for users (scientific / technical) in the main theoretical and practical foundations for handling results and their interpretation.
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