• SARS-COV-2 INFECTION: DIFFERENTIAL MANIFESTATIONS AND UPDATED TREATMENT Main objective To study the clinical and microbiological evolution of COVID-19 in the different waves of the pandemic and compare the clinical characteristics between patients who require hospital admission due to their severity with those of those that can be treated on an outpatient basis. – To precise characterization of the behavior of COVID-19 currently, and provide clues about the most appropriate measures to take once social distancing measures can be relaxed without putting the population at risk. most vulnerable population

• THROMBOEMBOLIC DISEASE. PREVENTION, DIAGNOSIS AND TREATMENT Main objectives: Improve the diagnosis, treatment, prognosis and monitoring of patients with VTE. Improve VTE prevention (Thromboprophylaxis). Transmit our knowledge to Hospital and Primary Care professionals. Spread knowledge of VTE to patients themselves and to society in general.

• SYSTEMIC AUTOIMMUNE DISEASES: MECHANISMS, DIAGNOSIS AND CURRENT TREATMENTS. The research of this group focuses on four main areas. Systemic lupus erythematosus, antiphospholipid syndrome and systemic sclerosis Sjögren’s syndrome, autoimmune manifestations of hepatitis C virus infection and biological therapies Systemic vasculitis Autoinflammatory diseases

• HEART FAILURE. MECHANISMS, DIAGNOSIS, AND TREATMENT UPDATE: The The mechanisms of Coronary Microvascular Dysfunction (CMD) Leading to Preheart Failure with Preserved Ejection Fraction (HFpEF) aims to people with suspected cardiac ischemia but without obstructive coronary artery disease to understand better understand the associated risks of heart damage and early mortality, as well as potential targets for HFpEF treatment and prevention.

• VASCULAR RISK AND INFLAMMATION: PREVENTION, DIAGNOSIS AND TREATMENT: In atherosclerosis, there is a hardening of the arteries and an accumulation of fat and cholesterol that prevents good blood flow. Despite these characteristics, during the first years of the disease, atherosclerosis may not show symptoms in the patient and, therefore, it is vitally important to identify new risk factors capable of predicting the evolution of the disease in people who do not yet manifest. clinical sequelae.

• CLINICAL ULTRASOUND IN INTERNAL MEDICINE: clinical ultrasound as another complementary tool for the internist (which helps him solve the specific problem for which the patient consults, what they call second level ultrasound, more exhaustive and usually performed by radiologists. Main objectives: Improve the clinical history and physical examination from this global and comprehensive approach. Promote the targeted use of clinical ultrasound in the consultation (point of care) to document the clinical diagnosis, making it more decisive and more effective

• DIGITAL MEDICINE Digital Health Research is to investigate, develop and innovate in the use of Information and Communications Technologies (ICT) in Health, with the aim of improving the health and well-being of people. To carry out this activity, the Unit is currently organized into 4 areas: Interoperability and Information Systems, Platforms and Devices, Clinical Validation and Evaluation.

Lines of study framed in basic research projects:

• Study of the pathophysiological role of nicotinica7 and dup-a7 receptors expressed in human macrophages, neurons and lung carcinoma cells.

• Identification of signalling pathways connecting nicotinic alpha7 receptors and negative regulators of TLRmediated inflammation in human macrophages.Molecular mechanisms involved in the innate immune response.