Presentación    
ANIMAL AND CELL MODELS FOR DETECTION AND
CHARACTERISATION
OF LEUKEMIC STEM CELLS
Composition
 
Name
Position
Institution
Carmela Calés Bourdet
Profesora Titular Departamento de Bioquímica. Facultad de Medicina
Universidad Autónoma de Madrid
Mónica Bravo Madrigal
Investigadora Predoctoral
Universidad Autónoma de Madrid
Miguel Ramón Campanero
García
Científico Titular
IIB "Alberto Sols"
Miguel Ángel Canales Albendea
Jefe de Sección de Hematología
Hospital Universitario La Paz
Raquel de Paz Arias
Facultativo Especialista de Área en Hematología
Hospital Universitario La Paz
Bárbara Fernández Morales
Investigadora Predoctoral
Universidad Autónoma de Madrid
Dolores Hernández Maraver
Facultativo Especialista de Área en Hematología
Hospital Universitario La Paz
Ana Kerguelen Fuentes
Facultativo Especialista de Área en Hematología
Hospital Universitario La Paz
Yenny Montenegro Medina
Investigadora Postdoctoral
Universidad Autónoma de Madrid
Marta Morado Arias
Técnico de Laboratorio
Hospital Universitario La Paz
Gema Pérez Chacón
Investigadora Postdoctoral
IIB "Alberto Sols"
Juan Manuel Zapata Hernández
Científico Titular
IIB "Alberto Sols"
Strategic Objective
Proper homeostasis of stem cells and pluripotent progenitor is pivotal to the development of haematopoietic proliferative disorders such as myelodysplastic or myeloproliferative syndromes, leukaemia and lymphoma. It is well known that alterations in transcriptional programs lead to transformed phenotypes, which are at the basis of the insidious acquisition of stem-like phenotypes of immature cells. Our group is interested in the role of transcriptional regulators, global regulators such as c-myc, c-myb, E2F and epigenetic controllers such as PcG factors in limiting the self-renewal capacity of common myeloid and lymphoid progenitors.
Our group has two main activities: basic research aimed to unravel the molecular mechanisms responsible for the acquisition of malignant haematological phenotypes (mouse models as well as ex vivo cell models to approach the questions outlined above); and research aimed to document clinical parameters and molecular markers that may be of use to a better understanding of the progression and outcome of haematological diseases, mainly myelodysplasia, lymphoma and multiple myeloma.
Research Lines
Role of epigenetic and transcriptional regulators in myelodysplasia: cellular and animal models
• Molecular and cellular basis of lymphoid neoplasias: non Hodgkin lymphomas and chronic lymphocytic leukaemia.
• Molecular markers of haematological malignancies.