Presentación    
DIAGNOSIS AND TREATMENT OF DISEASES ASSOCIATED WITH ABNORMALITIES OF THE COMPLEMENT SYSTEM
Composition
Name
Position
Institution
Margarita López Trascasa
Facultativo Especialista de Área en Inmunología
Profesor Asociado de la Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
Pilar Sánchez-Corral Gómez
Investigadora Senior (Contrato Miguel Servet - I2). Jefe de Laboratorio
Hospital Universitario La Paz
Fernando Corvillo Rodríguez
Investigador Predoctoral
Hospital Universitario La Paz
Sofía Garrido Herrero
Técnico de Laboratorio
Hospital Universitario La Paz
Alberto López Lera
Investigador Postdoctoral. Contratado CIBERER
Hospital Universitario La Paz
Marta Melgosa Hijosa
Facultativo Especialista de Área en Nefrología Infantil
Hospital Universitario La Paz
Rocío Mena de la Cruz
Responsable de Laboratorio de Secuenciación
Hospital Universitario La Paz
Pilar Nozal Aranda
Investigadora Predoctoral
Hospital Universitario La Paz
Antonia Peña Carrión
Facultativo Especialista de Área en Nefrología Infantil
Hospital Universitario La Paz
Strategic Objective
This is a national reference group for the study of patients with primary or acquired defects in the complement system, and its research activity follows a clearly translational approach.
The main objectives of the group are the molecular identification and characterisations of disorders associated with complement defects. In this context, the group develops and applies various methodological strategies (immunological, biochemical and genetic) to detect clinically relevant deficiencies or functional defects in complement components. The lines of research are organised around the main diseases studied: 1) Primary deficiencies of individual components associated with
infectious or autoimmune processes; 2) Genetic or acquired defects that cause renal pathology; and 3) Defects related to hereditary angioedema.
The group seeks to understand the molecular mechanisms of diseases related to the complement system, the majority of which are rare diseases. In addition, they develop new diagnostic tests of considerable usefulness in the clinical practice, especially for treatment adjustment and patient follow-up.
Research Lines
• Screening and characterization of complement defects in renal pathology
• Biochemical and molecular diagnosis of deficiencies of individual components of the complement system
• Diagnosis, molecular studies and screening for diseasemodifying genes in Hereditary Angioedema