Presentación
TRANSLATIONAL RESEARCH IN PEDIATRIC ONCOLOGY, HEMATOPOIETIC TRANSPLANTATION AND CELL THERAPY

cancerinfantil@idipaz.es

Excellent Group
Composition
Name
Position
Institution
Antonio Pérez Martínez
Facultativo Especialista de Área en Pediatría, Oncología y Hematología
Hospital Universitario La Paz
Cristina Aguirre Pórtoles
Project Manager
FIBHULP
Halin Bareke
Investigadora Postdoctoral
FIBHULP
Saturnino Barrena Delfa
Facultativo Especialista de Cirugía Pediátrica
Hospital Universitario La Paz
David Bueno Sánchez
Facultativo Especialista de Área en Pediatría, Oncología y Hematología
Hospital Universitario La Paz
Adela Escudero López
Investigadora Postdoctoral
FIBHULP
Mikel Fernández Artacoz
Médico Interno Residente en Hematología y Hemoterapia
Hospital Universitario La Paz
Berta González Martínez
Facultativo Especialista de Área en Pediatría
Hospital Universitario La Paz
Pilar Guerra García
Facultativo Especialista de Área en Pediatría, Oncología y Hematología
Hospital Universitario La Paz
Elisa Izquierdo Delgado
Investigadora Postdoctoral
FIBHULP
Manuel Izquierdo Pastor
Investigador Científico CSIC
IIB "Sols-Morreale"
Adriana Mañas Núñez
Investigador Posdoctoral
FIBHULP
Carla Martín Cortázar
Investigadora Postdoctoral
FIBHULP
Laura Martín Fernández
Gestora de Propiedad Intelectual
FIBHULP
Isabel Martínez Romera
Facultativo Especialista de Área en Pediatría
Hospital Universitario La Paz
Carmen Mestre Durán
Investigadora Predoctoral
FIBHULP
Antonio Jesús Muñoz Serrano
Facultativo Especialista de Área en Cirugía Pediátrica
Hospital Universitario La Paz
Alfonso Navarro Zapata
Investigador Predoctoral
Hospital Universitario La Paz
Gema Pérez Chacón
Investigadora Senior
IIB "Sols-Morreale"
Pedro María Rubio Aparicio
Facultativo Especialista de Área en Pediatría, Oncología y Hematología
Hospital Universitario La Paz
Beatriz Ruz Caracuel
Investigadora Bioinformática
Hospital Universitario La Paz
Javier Ruiz Navarro
Investigador Predoctoral
IIB "Alberto Morreale"
Sonsoles San Román Pacheco
Facultativo Especialista de Área en Pediatría, Oncología y Hematología
Hospital Universitario La Paz
Clara María Venegas Mascaró
Investigadora Predoctoral
FIBHULP
Juan Manuel Zapata Hernández
Research Scientist CSIC
IIB "Sols-Morreale"
Strategic Objective
Our research program focuses on the molecular and immunological characterization of childhood cancer; the development of cell therapies, primarily through the susceptibility of tumor cells to Natural Killer cells; and the optimization of hematopoietic stem cells  transplantation.
Research Lines
• Analysis of solid / hematological tumors samples to determine their susceptibility to cell therapy, at functional, protein expression and genetic level.
• Cell therapy with activated NK cells in childhood cancer.
• Hematopoietic progenitor transplantation as a platform for cell therapy.
• Cell therapy with memory T lymphocytes as adoptive immunotherapy in transplantation of haematopoietic progenitors.
• Optimization of cell therapy by the generation of an NKG2D antigenic chimeric receptor (NKG2D-CAR). Evaluation of its specificity, persistence and activity (in vitro and in vivo) for the treatment of childhood cancer.
• Optimization of NK cell therapy using nanotechnology and antigenic chimeric receptors (CAR).
• Induction of immunological tolerance in solid organ transplantation through the induction of hematopoietic mixed chimerism by cell therapy
• Development of academic clinical trials and collaborations with the pharmaceutical industry as a strategy for the development of new therapies more effective and with fewer side effects in childhood cancer.
• Cell therapy with citokine induced-memory like NK cells for pediatric solid tumors.
• Cell therapy with memory T lymphocytes from COVID-19 convalescent donors as an innovative therapy for COVID-19.