Presentación
PEDIATRIC SYSTEMIC INFECTIONS; HIV, TUBERCULOSIS, IMPORTED AND EMERGENT DISEASES

infeccionessistemicasenpediatria@idipaz.es

Excellent Group
Composition
Name
Position
Institution
Talía Sainz Costa
Facultativo Especialista de Área en Pediatría
Profesora Asociada
Hospital Universitario La Paz
Universidad Autónoma Madrid
Jorge Atucha Margolles
Técnico de Laboratorio
FIBHULP
Fernando Baquero Artigao
Facultativo Especialista de Área de Pediatría 
Profesor Colboarador
Hospital Universitario La Paz
Universidad Complutense de Madrid
Blanco Bravo Queipo de Llano
Facultativo Especialista de Área de Pediatría
Hospital Universitario La Paz
Jorge Bustamante Amador
Investigador Predoctoral
Hospital Universitario La Paz
Francisco José Climent Alcalá
Facultativo Especialista de Área de Pediatría. Unidad de Patología Compleja
Colaborador docente
Hospital Universitario La Paz
Univesidad Autónoma de Madrid
Lucía Escolano Taravillo
Investigador Predoctoral
Hospital Universitario La Paz
Luis Escosa  García
Facultativo Especialista de Área en Pediatría
Hospital Universitario La Paz
Jaime Delgado Pérez
Investigador Predoctoral
Hospital Universitario La Paz
Miguel García Boyano
Investigador Predoctoral
Hospital Universitario La Paz
Marta García Fernández de Villalta
Facultativo Especialista de Área de Pediatría
Colaborador Clínico Docente
Hospital Universitario La Paz
Univesidad Autónoma de Madrid
María Milagros García López de Hortelano
Médico Adjunto de Pediatría Hospitalaria y Enfermedades Infecciosas y Tropicales
Colaborador Clínico Docente
Hospital Universitario La Paz
Universidad Autónoma de Madrid
Isabel Mellado Sola
Médico Interno Residente
Hospital Universitario La Paz
María Pérez Pascual
Médica Adjunta en Pediatría
Hospital Universitario La Paz
Roi Piñeiro Pérez
Jefe Asociado del Servicio de Pediatría
Hospital General de Villalba
Paula Rodríguez Molino
Contrato Rio Hortega
Hospital Universitario La Paz
Germán Vallejo Palma
Investigador Predoctoral
Fundación GESIDA
Strategic Objective
1. Vertically acquired HIV infection in children: Comorbidities,  biomarkers, HIV reservoir, new therapeutic approaches.
2. Epidemiology of Paediatric Tuberculosis is Spain: molecular epidemiology of drug resistant strains, new diagnostic tools and new drugs for TB: Pharmacodynamics in children and TB-drugs Off-label use in paediatrics.
3. Congenital infections: burden of disease, prompt diagnosis and in-utero and postnatal management, host immune response.
4. Epidemiology of imported and emergent diseases in children: Identification and management of emergent outbreaks. Immuno-pathogenesis, preventive measures and management.
5. Immunization strategies in children: immune response in high risk patient’s vaccine effectiveness and barriers.
Research Lines
 
• Vertically acquired HIV infection in children
- Immuno-pathogenesis: Immune-activation, inflammation and biomarkers
- Epidemiology, immuno-virological factors
- Comorbidities, long term follow-up, cardiovascular risk, bone disorders, metabolic abnormalities, neurocognitive impairment, renal dysfunction.
- Antiretroviral treatment: new drugs, resistances, dosage, toxicity in children, simplification strategies.
- HIV eradication: barriers, HIV reservoir, new antiretroviral drugs and other strategies to achieve HIV replication control.
- Gut Microbiota and bacterial traslocation intestinal as modulating factors for inflammation and immune-activation in HIV-infected  children.
- Transition to adult care: barriers, strategies to maintain adherence to care.   
• Epidemiology of paediatric Tuberculosis (TB).
- Epidemiology of paediatric TB. Paediatric cases as as a sentinel for burden of diseases.
- Molecular epidemiology of paediatric TB: resistant strains.
- Immuno-pathogenesis: New diagnostic tools in special Populations: HIV-infected, ID patients, migrants and Internationally adopted children
- Management of critical situations. Neonatal TB, multidrug resistant and extra-pulmonary TB.
• Omics for the diagnostis of pediatric TB
- New fixed-dosed combinations. Off label drugs in children. Pharmacodinamic and  pharmacokinetic
Congenital infectious disease
- Congenital Citomegalovirus and Toxoplasma infections: diagnostic barriers, prognostic factors, new therapeutic approaches.
- CHAGAS disease and congenital TB: diagnostic barriers, prognostic factors, pharmacokinetics in newborns and new drugs.
Epidemiology of imported and emergent diseases in children
- Paediatric International Outbreaks: Epidemiology and public health impact:  Zika. Rabies. Dengue. Chikungunya. Haemorragic fevers, Mers-co.
- Imported diseases in Spain: epidemiology and special populations: adopted, migrant, refugees, travelers and ID children
- Covid-19 disease in children: epidemiology, diagnostic markers,treatment.
 Immunization strategies in children, including high risk patients
- Immunization and vaccine response in special populations: immunocompromised children, transplant recipients, chronic patients, HIV-infected, migrants.
- Vaccine immunogenicity: barriers in paediatric populations.
- New challengies in vaccinology
• Microbiome in pediatric infectious diseases
- Microbiome-related biomarkers in food allergy and intolerances
- Microbiome-related biomarkers in childhood TB and other respiratory infections 
- Social Determinants of Health in Pediatrics 
- The burden of chronic disease in childhood 
- Health-care associated Infections. 
- The burden of antimicrobial resistance
- Antimicrobial stewardship in pediatrics