Presentación
MECHANISMS AND BIOMARKERS IN NEURODEGENERATIVE DISEASES
EnfermedadNeurodegenerativaMolecular@idipaz.es
Composition
Name
Position
Institution
Isabel Lastres Becker
Profesora Titular 
Universidad Autónoma de Madrid
Marina Arribas Blázquez
Investigadora Postdoctoral
Universidad Autónoma de Madrid
Silvia Constanza Contreras Jurado
Titulado Superior de Actividades Técnicas y Profesional
Centro Superior de Investigaciones Científicas
Ignacio Silva Llanes
Investigador Predoctoral
Universidad Autónoma de Madrid
Strategic Objective
The aging of the population poses a growing burden in society. This is associated with the increase in disability and diseases that have a high impact on health care, on patients and their families. Likewise, aging is associated with the appearance of different neurodegenerative diseases, among which include Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). Therefore, the development of advanced biological markers, new drugs and appropriate technology is the key to establishing a treatment for these diseases, which is currently an important social challenge. In our laboratory we study the molecular basis of neurodegeneration. The research projects we develop have a multidisciplinary approach that combines basic and translational research, using cell culture techniques, murine models and postmortem samples from patients with AD, PD and ALS.
Research Lines
• Implication of alterations at the mitochondrial and mitophageal level in Parkinson's Disease
• New therapeutic strategies for diseases with alterations in the TAU protein, such as Alzheimer's disease. We have two different approaches to this:
- Modulation at the epigenetic level
- Involvement of the cannabinoid system
• Development of new therapeutic strategies for amyotrophic lateral sclerosis: analysis of RNA metabolism and stress granule formation