Presentación
BONE PATHOPHYSIOLOGY AND BIOMATERIALS


fisiopatologiaoseaybiomateriales@idipaz.es
Composition
Nombre
Composición
Institución
Nuria Elda Vilaboa Díaz
Investigadora Senior (Contrato Miguel Servet - I2)
Jefe de Laboratorio
FIBHULP
Fátima Bensiamar Hadia
Técnico de Laboratorio
FIBHULP
Clara Escudero Duch
Investigadora Predoctoral
FIBHULP
Marcos de Mesa Cáceres
Ténico de Laboratorio
FIBHULP
Mabel Falguera Uceda
Investigadora Predoctoral
Hospital Universitario La Paz
Eduardo García Cimbrelo
Jefe de Servicio de Cirugía Ortopédica y Traumatológica A
Profesor Asociado. Departamento de Cirugía. Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
Enrique Gil Garay
Jefe de Servicio de Cirugía Ortopédica
y Traumatológica B
Profesor Titular. Departamento de Cirugía. Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
Cecilia Huarte Sebastián
Investigadora Predoctoral
FIBHULP
Miguel Ángel Lerma Juárez
Investigador Predoctoral
FIBHULP
Leila Maestro Paramio
Investigadora Predoctoral
FIBHULP
Carmen Martin Hervás
Facultativo Especialista de Área en
Radiodiagnóstico
Profesora Asociada. Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
Alonso Carlos Moreno García
Facultativo Especialista de Área en Cirugía Orotopédica y Traumatología
Hospital Universitario La Paz
Laura Saldaña Quero
Investigadora Senior (Contrato Miguel Servet-Tipo I)
Jefe de Laboratorio
FIBHULP
Silvia Sánchez Casanova
Ayudante de Investigación 
FIBHULP
Gema Vallés Pérez
Investigadora Senior. Responsables de Cultivos Celulares y de los Laboratorios Comunes de IdiPAZ
FIBHULP
 
Strategic Objective
The Bone Physiopathology and Biomaterials group includes basic and clinical researchers from IdiPAZ. The group has broad experience in clinical and basic research on biomaterials for orthopaedic implants and bone tissue engineering. The principal goal of the group is to improve the clinical outcome of orthopaedic surgery through research on implants and biomaterials used for manufacturing prosthetic devices. The group is also interested in bone tissue engineering applications, developing surgical procedures that make use of allotransplants, evaluating scaffolds manufactured by collaborative partners, developing novel gene therapy strategies aimed to heal bone defects and studying the interactions of the immune and skeletal systems. Specific areas of clinical research on implants include follow-up studies on various devices in use for osteoarticular surgery. The main areas of interest in basic research on the biocompatibility of materials include:
a) understanding the influence of the surface biomaterial properties on the behaviour of bone-related cells
b) the study of cell reactions occurring in the vicinity of implanted materials caused by wear particles
c) the deliberate manipulation of cell responses after exposure to nanoparticles designed for gene delivery and optical hyperthermia applications.
The team is also interested in the development of transcriptional targeting strategies to ensure tight control of the expression of therapeutic proteins and their potential application in inducing an orchestrated expression of growth factors involved in bone healing.
Research Lines
• Biocompatibility of new materials for potential use in implants for bone repair: cell and surface interactions, cell and particle interactions
• Study of the interactions between the immune and skeletal systems
• Control of the expression of therapeutic genes using gene circuits