This research area, has been developed along the last 25 years by our group, with outstanding contributions to several aspects of the field, ranging from basic science (endothelial function, role of lab and image biomarkers, magnetoelectroencephalography, musculoskeletal function…) to clinical and epidemiological research, raising data that have allowed to promote technological devices (platform to detect, treat and monitor functional decline in an non-obtrusive way) and leading to the creation of a technological SME (MG Biomed) .