The global objective of the investigation team on Dysfunction and Organ Failure in Aggression is the optimization of the patient management in the really critical ill patients who can develop organ dysfunction or organ failure. Multiorgan Dysfuntion & Multiorgan Failure Syndrome (MOF-MOD Syndrome) are correlated with bad prognostic and high mortality rates.
D-FMO Syndrome is correlated both with the disease severity and the therapeutic efforts. The therapeutic management of the patient must be early and directed to specific objectives.
Otherwise, the support measures must be directed to the specific situations (like sepsis, trauma…) and to the Organs or Systems in Dysfunction or Failure (coagulation, haemodynamic, respiratory or renal...) Finally, the detection or D-FMO Syndrome employing not only single markers (clinic) but early and organ specific biomarkers (basic or advanced biochemical markers, molecular markers…) can bring a higher efficacy and better results.