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Strategic Objective
The research group conducted by Dr. García-Samaniego has extensive experience in the study of liver diseases, focusing its research activity, in both, clinical and basic aspects. In recent years the group has developed its activity preferentially in the study of viral hepatitis. The expertise areas of the research group are the study of infections caused by the hepatitis viruses [hepatitis viruses B (HBV), C (HCV) and delta (HDV)] and the chronic liver disease related to HBV, HCV and HDV at a time in which highly efficient antiviral systems against HBV, and especially against HCV has been developed.
In addition to complete the research lines, the global strategy of the group will be focused in maintaining the high level of collaboration, both with CIBERehd research groups and with external groups, as well as to increase of the cooperation ways with private enterprise.
Research Lines
Main research lines:
1 Study of the epidemiological situation and optimization of the cascade of care for patients with infection by the hepatitis delta virus (HDV). Project in collaboration with the Hospital Clinic of Barcelona and Infanta Leonor of Madrid, and funded by the HDV DESCRIBE program sponsored by Gilead Scientific, S.A.
2 Development of HCV micro-elimination strategies through the optimization and implementation of HCV detection and quantification systems at diagnostic points.
3 Analysis of the role of epigenetic modifications induced by infection by hepatotropic viruses in the evolution of liver disease and the development of liver cancer, before and after antiviral treatment. Project performed in collaboration with the Department of Biochemistry of the Faculty of Medicine of the UAM and the Virology laboratory of the Molecular Biology Center "Severo Ochoa".
4 Study of liver fibrosis progression factors in patients with metabolic hepatic steatosis.
Alternative lines of work:
1 Study of the role of the intestinal microbiota as a prognostic factor for adverse effects in biological cancer therapy. Project developed in collaboration with the Department of Biochemistry of the Faculty of Medicine of the UAM.
2 Study of the influence of pre-existing liver disease on the evolution of COVID.
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