Presentación
   
NEUROLOGY AND
CEREBROVASCULAR DISEASES
 
Excellence Group
Composition
Name
Position
Institution
Exuperio Díez Tejedor
Jefe de Servicio de Neurología
Catedrático del Departamento de Neurología. Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
María José Aguilar-Amat Prior
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
María Alonso de Leciñana Cases
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Joaquín Arcas Martínez
Facultativo Especialista de Área en Neurología Pediátrica
Hospital Universitario La Paz
Juan José Arévalo Manso
Enfermero
Hospital Universitario La Paz
Francisco Javier Arpa Gutiérrez
Profesor Asociado Facultad de Medicina
Universidad Autónoma de Madrid
María Jesús Bullido Gómez-Heras
Profesor Titular. Departamento de Biología Molecular. Facultad de Ciencias
CBM "Severo Ochoa"
Fernando Carceller Benito
Facultativo Especialista de Área en Neurocirugía
Hospital Universitario La Paz
Sebastián Cerdán García-Esteller
Investigador Postdoctoral. Laboratorio de Imagen y Espectroscopia por Resonancia Magnética
IIB "Alberto Sols"
María Delia Chaverri Rada
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz 
Jorge Eduardo Collazos Castro
Jefe de Laboratorio de Reparación Neural y Biomateriales
Hospital Nacional de Parapléjicos de Toledo
Josué Fernández Carnero
Profesor e Investigador Postdoctoral
Centro Superior de Estudios Universitarios La Salle
Andrés Francisco Fernández Prieto
Facultativo Especialista de Área en Radiología
Hospital Universitario La Paz
Mireya Fernández-Fournier Fernández
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz 
Ana Frank García
Jefe de Sección en Servicio de Neurología
Profesora Titular de Neurología. Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
Remedios Frutos Martínez
Facultativo Especialista de Área en Radiología
Hospital Universitario La Paz
Blanca Fuentes Gimeno
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Alfonso Gil Martínez
Fisioterapeuta
Hospital Universitario La Paz
David Gómez Andrés
Investigador Predoctoral. Departamento de Anatomía, Histología y Neurociencia
Universidad Autónoma de Madrid
Ana Cristina Guadaño Ferraz
Científico Titular. Departamento de Fisiopatología Endocrina y del Sistema Nervioso
IIB "Alberto Sols"
María Dolores Gutiérrez Fernández
Investigadora Postdoctoral. Laboratorio de Neurociencias y Enfermedades Cerebrovasculares
Hospital Universitario La Paz
María Hernández Barral
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Rafael Herruzo Cabrera
Jefe de Sección de Medicina Preventiva y Salud Pública
Catedrático Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
Vicente Iváñez Mora
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Roy La Touche Arbizu
Profesor Titular
Centro Superior de Estudios Universitarios La Salle
Manuel Lara Lara
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Jesús María López Arrieta
Jefe de Sección de Geriatría
Profesor Asociado de Prácticas. Facultad de Psicología
Hospital de Cantoblanco – Hospital Universitario La Paz
Universidad Autónoma de Madrid
María Pilar López Larrubia
Científica Titular. CSIC
IBB "Alberto Sols"
Ibai López de Uralde Villanueva
Investigador Predoctoral
Centro Superior de Estudios Universitarios La Salle
Genny Lubrini
Investigadora Postdoctoral. Servicio de Neurología
Hospital Universitario La Paz
Begoña Marín Aguilera
Facultativo Especialista de Área en Radiología
Hospital Universitario La Paz
Juan Andrés Martín Gonzalo
Profesor Titular
Escuela Universitaria de Fisioterapia de la ONCE
Ángel Martín Montes
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Antonio Martínez Bermejo
Jefe de Servicio de Neurología Pediátrica
Profesor Asociado. Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
Mercedes Martínez Moreno
Facultativo Especialista de Área en Medicina Física y Rehabilitación
Hospital Universitario La Paz
Patricia Martínez Sánchez
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Susana Moraleda Pérez
Jefe de Sección de Medicina Física y Rehabilitación
Hospital Universitario La Paz
Pilar Negredo Madrigal
Profesor Interino. Departamento de Anatomía, Histología y Neurociencia
Universidad Autónoma de Madrid
Susana Noval Martín
Facultativo Especialista de Área en Oftalmología
Hospital Universitario La Paz
Jesús Oliván Palacios
Facultativo Especialista de Área en Neurofisiología Clínica
Hospital Carlos III -
Hospital Universitario La Paz
Laura Otero Ortega
Investigadora Postdoctoral (Contrato Sara Borrell)
Hospital Universitario La Paz
Joaquín Pardo Montero
Profesor Titular
Centro Superior de Estudios Universitarios La Salle
Alba París Alemany
Profesora. Investigadora Predoctoral
Centro Superior de Estudios Universitarios La Salle
Samuel Ignacio Pascual Pascual
Jefe de Sección de Neurología Pediátrica
Profesor Asociado. Facultad de Medicina
Hospital Universitario La Paz
Universidad Autónoma de Madrid
José Francisco Paz Solís
Facultativo Especialista de Área en Neurocirugía
Hospital Universitario La Paz
Inmaculada Puertas Muñoz
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Irene Pulido Valdeolivas
Investigadora Predoctoral. Departamento de Anatomía, Histiología y Neurociencia
Hospital Universitario La Paz
Estrella Rausell Tamayo
Catedrática. Departamento de Anatomía, Histología y Neurociencias. Facultad de Medicina
Universidad Autónoma de Madrid
José María Roda Frade
Jefe de Servicio de Neurocirugía
Hospital Universitario La Paz
Irene Rodríguez Andonaegui
Profesor Ayudante
Escuela Universitaria de Fisioterapia de la ONCE
Berta Rodríguez Frutos
Investigadora Postdoctoral. Laboratorio de Neurociencias y Enfermedades Cerebrovasculares
Hospital Universitario La Paz
Francisco Javier Rodríguez de Rivera Garrido
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Aranzazu Royo Orejas
Jefe de Sección de Radiología
Hospital Universitario La Paz
Gerardo Ruiz Ares
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
María Teresa Salas Campos
Técnico Superior Psicología. Servicio de Neurología
Hospital Universitario La Paz
Patricia Sánchez García
Técnico de Laboratorio
Hospital Universitario La Paz
Susana Santiago Pérez
Facultativo Especialista de Área en Neurofisiología
Hospital Universitario La Paz
Borja Enrique Sanz Cuesta
Facultativo Especialista de Área en Neurología (Contrato Río Hortega)
Hospital Universitario La Paz
Antonio Tallón Barranco
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Gema Torrijos Barbero
Especialista en Neuropsicología. Unidad de Memoria y Demencias
Hospital de Cantoblanco-Hospital Universitario La Paz
Arturo Ugalde Canitrot
Facultativo Especialista de Área en Neurofisiología Clínica
Hospital Universitario La Paz
Francisco Vivancos Matellano
Facultativo Especialista de Área en Neurología
Hospital Universitario La Paz
Strategic Objective
 
The research of this group is distributed in the following areas:
CEREBROVASCULAR
• Development of translational research studies (both animal and clinical studies) in cerebrovascular diseases, with the objectives of increasing the understanding of the pathogenesis of both cerebral infarction (with cortical and subcortical affectation) and cerebral hemorrhage. To identify prognostic biomarkers and therapeutic targets mainly aimed at the promotion of brain protection and repair, with a special interest on the development of cell therapy as well as in trophic factors, extracellular vesicles and remyelinizating drugs. Clinical trials of cell therapy in acute cerebral infarction (clinical trial AMASCIS and European Consortium RESSTORE-H2020).
• Development of innovative strategies in the diagnosis and treatment of ischemic stroke, through the development of an independent operator-ultrasound device for brain visualization and for enhancement by ultrasound of drug therapies (BDNF, exosomes) in the ischemic area.
• Evaluation of the benefit of the implementation of prehospital clinical scales able to identify of patients of cerebral artery occlusion susceptible to mechanical thrombectomy in order to shorten treatment delay and improve the prognosis of patients. Comparative analysis of benefit and risk of primary mechanical thrombectomy versus intravenous throm-bolysis in patients with acute ischemic stroke within the first 4.5 hours from onset.
• Study of the clinical (neurological and neuropsy-chological) and anthropological factors influencing functional recovery and reintegration of stroke pa tients as well as the compliance with the recommendations for secondary stroke prevention.
HEADACHES AND NEUROPATHIC PAIN
• Analysis of the expression of the phenomenon central painful awareness in different primary and secondary headaches.
NEURODEGENERATION 
Amyotrophic Lateral Sclerosis
• ECAS scale (Edinburgh Cognitive Assessment Scale) validation and adaptation to Spanish language. Analysis of the different profiles of cognitive impairment in ALS patients by means of the ECAS scale (Edimburgh Cognitive Assesment Scale).
• SOPHIA Project: European Project on harmonization and optimization of the production and procesing of samples for the study of biomarkers in ALS and other motor neuron diseases.
• Functional study of Autonomic Nervous System in Amyotrophic Lateral Sclerosis. Identification of differential patterns of the disease presentation and their impact on clinical outcome . Alzheimer´s disease.
• Study of the lysosomal pathway involvement in a model of neurodegeneration and cholesterol dysregulation in Alzheimer’s disease. Parkinson´s disease.
 • Tremor as a negative predictive factor in developing dementia associated with Parkinson’s disease.
 • Evaluation of the benefits and risks of continuous infusion of intraduodenal levodopa in idiopathic Parkinson’s disease. Hereditary ataxias
• Assessment of therapeutic response to Frenkel training exercises enhanced by Wii game console in patients with cerebellar ataxia.
• Participation in the Registry of the European Consortium EFACTS (European Friedreich’s Ataxia Consortium for Translational Studies) aimed at improve the knowledge of the epigenetic mechanisms related to silencing the expression of frataxin and the pathogenesis of the disease, identification of biomarkers and genes modifying the clinical expression of the disease, development of new therapies as well as cellular and animal models for the study of Friedrich’s Ataxia. 
COGNITION, BEHAVIOR AND NEUROLOGICAL ANTHROPOLOGY
• Analysis of the medium and long term results of workshops on post-stroke care attended by family and patients during the hospitalization time for an acute stroke on the degree of knowledge and ack - nowledge of stroke and its risk factors.
• Evaluation of the perceived quality of physicianpatient-family communication in cerebrovascular diseases and dementias.
NEUROIMMUNOLOGY
Multiple sclerosis
• Study of remyelinizators substances as a biomarker white matter lesion in multiple sclerosis patients.
• Analysis of white matter biomarkers in Theiler’s Mourine Encephalomyelitis Virus (TMEV) animal model. Development of new reparative therapies based on the enhancement of remyelinization in experimental animal model.
• Analysis of molecular and neuroimaging biomarkers of brain damage and repair in Multiple Sclerosis. 
AUTONOMIC NERVOUS SYSTEM
• Evaluation of the Autonomic Nervous System in movement disorders.
• Evaluation of the Autonomic Nervous System in focal autonomic neuropathies and in Fabry disease.
• COMPASS-31 Study (collaboration with the Mayo Clinic): Registry of patients and controls with central and peripheral dysautonomia.
NEUROMUSCULAR DISEASES
• Observational study of the clinical course of patients with Charcot-Marie-Tooth disease. Identification of prognostic factors.
• Efficacy of evaluation of Eslicarbazepine acetate in neuropathic pain in patients with peripheral neuropathies.
SLEEP
• Development and evaluation of intervention protocols in childhood insomnia treatment.
• Analysis of sleep microstructure in newborns with Prader Willi Syndrome.
• Study on the efficacy of child insomnia treatment with oral iron supplements against placeb.
EPILEPSY
• Evaluation of the benefit of the implementation of an outpatient clinic for first seizures.
• Analysis of factors influencing the recurrence of seizures, tolerance and adherences to drugs, during the first monotherapy in patients with epilepsia.
• Analysis of neuropsychological disorders in the primary generalized epilepsy.
• Evaluation of cognitive impact of antiepileptic treatment after the first seizure and at the start of the first monotherapy as well as in elderly patients with focal epilepsy.
• Influence of stress as a trigger of seizures in epilepsy.
• Depression and anxiety: impact on the therapeutic compliance of patients with epilepsy.
• Registry of patients treated with i.v. antiepileptic drugs. Analysis of indications, response and adverse events.
BRAIN DEVELOPMENT DISORDERS
• Study and functional classification of the gait of pediatric patients with cerebral palsy.
• Study and functional classification of the gait of patients with familial spastic paraparesis.
• Gait analysis as a tool for the differential diagnosis bet - ween child cerebral palsy and PEF in paediatric patients.
Research Lines
• Cerebrovascular diseases.
• Neurodegenerative diseases.
• Neuroimmunology. Multiple sclerosis.
• Neuromuscular diseases and spinocerebellar ataxias. Motor neuron diseases Amyotrophic lateral sclerosis.
• Headache and neuropathic pain.
• Developmental disorders and neurological maturation (TRADESMA).