• To promote and improve the quality of research in the field of Primary Health Care and Geriatrics in the area of influence of IdiPAZ.

• To continue the follow-up of the Cohorts of the Group: elderly people with population-based (Peñagrande Study), patients with frailty syndrome (FONDA) and patients with Type 2 Diabetes Mellitus (MADiabetes).

• Progress in the epidemiological study of frailty in the elderly.

• To consolidate clinical studies related to hip fracture and chronic diseases in the elderly, specially the Diabetes Mellitus.

• Frailty syndrome in the elderly. To promote the detection of frailty syndrome in elderly people above 75 years that consults at the Primary Heatlh Care Center of the Hospital La Paz Setting and create a new cohort of those patients with functional impairment. Additionally, to develop and evaluate an intervention program with these patients, focused on the physical exercise, the geriatric evaluation, management of comorbidity, in the medication adjustment y in nutritional supplementation when necessary.

• Hip fracture in the frail elderly. To evaluated the implementation and evaluation of the FONDA intervention with frail elderly patients hospitalized at the La Paz Hospital based on: physical exercise program (active and passive), early normalization of plasma levels of VitD, nutritional supplementation in patients with hypoproteinemia, low or vitamin D deficiency, and control of the pain and anemia.

• Follow-up of patients with Type 2 Diabetes Mellitus (MADiabetes Cohort, more than 3.500 patients) and prediabetes patients (SPREDIA Cohort, n=600) of Madrid, to analyze clinical and psychosocial factors related to clinical outcomes (cardiovascular events, chronic kidney disease, retinopathy, and mortality), we are developing predictive models for main outcomes (chronic kidney disease, all-cause mortality and cardiovascular mortality).