Presentación    
REGULATION OF GENE EXPRESSION
AND BY HYPOXIA
Composition
Name
Position
Institution
Luis del Peso Ovalle
Profesor Titular. Departamento de Bioquímica. Facultad de Medicina
Universidad Autónoma de Madrid
Benilde Jiménez Cuenca
Profesor Titular. Departamento de Bioquímica Facultad de Medicina
Universidad Autónoma de Madrid
María Tiana Cerrolaza
Investigador Predoctoral
Universidad Autónoma de Madrid
Strategic Objective
The elucidation of the cellular and molecular responses to changes in oxygen tension constitutes an exciting research topic given the dependence of virtually all human tissues on appropriate oxygen supply and the involvement of hypoxia in high-incidence pathologies such as cardiopulmonary diseases and cancer. The Hypoxia Inducible transcription Factor (HIF) plays a pivotal role in this response by controlling the expression of most of the genes involved in the adaptation to hypoxia. Our research group aims to provide novel insight into transcriptional response to hypoxia and to exploit this knowledge to improve clinical management of pathologies in which hypoxia is a common feature. To this end we are currently involved in the following.
Research Lines
• Identification of network motifs within the gene regulatory network regulated by HIF and study of their role in the adaptation to hypoxia.
• Characterization of the effect of hypoxia/HIF on endothelial cell proliferation and integration of this response in the induction of angiogenesis.
• Analysis of the functional effect of polymorphisms affecting HIF binding and investigation of their correlation with the different phenotypes in chronic respiratory diseases and cancer.