Presentación    
REGULATION OF GENE EXPRESSION
AND BY HYPOXIA
Composition
Name
Position
Institution
Luis del Peso Ovalle
Profesor Titular. Departamento de Bioquímica. Facultad de Medicina
Universidad Autónoma de Madrid
Benilde Jiménez Cuenca
Profesor Titular. Departamento de Bioquímica Facultad de Medicina
Universidad Autónoma de Madrid
María Tiana Cerrolaza
Investigador Predoctoral
Universidad Autónoma de Madrid
Strategic Objective
Oxygen is an essential element for the metabolism of all tissues. Therefore, cells respond to hypoxia by implementing a series of mechanisms directed at restoring an adequate supply of oxygen to tissues and maintaining appropriate generation of energy during hypoxia. These responses are mediated by molecular machinery in which the hypoxia inducible factor (HIF) plays a central role.
The fundamental objective of our group is to deepen our understanding of the molecular machinery of the hypoxia response. Specifically, we seek to identify, using a combination of bioinformatic and molecular biology techniques, the complement of genes induced by hypoxia through HIF and to characterise its function in the response to hypoxia. In addition to providing an overall view of the response to hypoxia, this research line may help identify genes that are useful markers for the diagnosis and monitoring of diseases that progress with the development of tissue hypoxia, such as neoplasms and respiratory and cardiovascular diseases.
Research Lines
• Identification of SNPs within HIF binding sites. Value as prognosis markers in COPD and SAHS
• Characterisation of the molecular mechanisms responsible for the transcriptional response to hypoxia