Presentación    
INNATE IMMUNE RESPONSE
 
Excellence Group
Composition
Name
Position
Institution
Eduardo Manuel López-Collazo
Director Científico de IdiPAZ.
Investigador Senior (Contrato Miguel Servet - I2)
Jefe de Laboratorio
Hospital Universitario La Paz
Susana Alemany de La Peña
Investigadora Senior
Jefe de Laboratorio
IIB "Alberto Sols"
José Avendaño Ortiz
Ayudante de Investigación
Hospital Universitario La Paz
Lisardo Boscá Gomar
Investigador Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Ramón Cantero Cid
Facultativo Especialista de Área en Cirugía General y de Aparato Digestivo
Hospital Universitario La Paz
José Germán Casas Martín
Investigador Predoctoral
Hospital Universitario La Paz
Antonio Castrillo Viguera
Investigador Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Raúl Córdoba Mascuñano
Facultativo Especialista de Área en Hematología
Hospital Fundación Jiménez Díaz
María Fernández Velasco
Investigadora Senior
(Contrato Miguel Servet- Tipo I)
IIB "Alberto Sols"
Marta Flández Canet
Investigadora Postdoctoral 
Hospital Universitario La Paz
Santiago Gómez Ruiz
Profesor Titular
Universidad Rey Juan Carlos
María Susana Guerra García
Investigadora Postdoctoral
Universidad Autónoma de Madrid
Enrique Hernández Jiménez
Investigador Predoctoral (Contrato Predoctoral)
Hospital Universitario La Paz
Teresa Jurado Camino
Investigadora Predoctoral
Hospital Universitario La Paz
Charbel Antonio Maroun Eid 
Facultativo Especialista de Área en Urgencias
Hospital del Norte
Paloma Martín Sanz
Investigadora Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Aurora Muñoz Jiménez
Técnico de Laboratorio
Hospital Universitario La Paz
Rebeca Pérez de Diego
Investigadora Senior (Contrato Ramón y Cajal)
Hospital Universitario La Paz
Antonio Pérez Martínez
Facultativo Especialista de Área en Pediatría
Hospital Universitario La Paz
Sanjiv Prashar
Profesor Titular
Universidad Rey Juan Carlos
Víctor Manuel Toledano Real
Técnico de Laboratorio (Contrato de Técnico de Apoyo)
Hospital Universitario La Paz
Aníbal Ramón Varela Serrano
Técnico de Laboratorio 
Hospital Universitario La Paz
Strategic Objective
This group focuses on the study of the reprogramming of the innate immune response in the context of inflammatory diseases (e.g., sepsis, cystic fibrosis, acute coronary syndrome, lung cancer) using the description of the various molecular mechanisms that underlie the reprogramming of monocytes/macrophages during refractory states.
The innate immune response is activated in various clinical contexts that can be modelled in vitro. The initial reaction of the Innate Immune System is marked by an inflammatory response that is similar in different contexts.
However, after the initial response, a “deviation” is produced towards an “alternative” response that may, in many cases, lead to refractory states such as endotoxin and tumour tolerance. These refractory states may have undesirable clinical consequences and their study is the objective of our research.
Research Lines
• Molecular mechanisms of endotoxin tolerance in several clinical contexts: respiratory diseases (COPD and cystic fibrosis), acute coronary syndrome, sepsis and septic shock
• Role of microRNAs in the activation of states refractory to endotoxins and tumours
• Role of TREM-1 as a marker of lung diseases
• Molecular mechanisms of the innate immune system tolerance to tumours
• Role of IRAK-M pseudokinase and TREM-1 receptor in endotoxin tolerance in various clinical contexts